The cell adhesion regulator (CAR) gene, TaqI and insertion/deletion polymorphisms, and regional assignment to the peritelomeric region of 16q by linkage analysis

Journal Article · Thu Apr 01 00:00:00 EST 1993 · Genomics; (United States)

DOI:https://doi.org/10.1006/geno.1993.1173· OSTI ID:6287886

Koyama, Kumiko; Emi, Mitsuru; Nakamura, Yusuke ^[1]

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1. Cancer Inst., Tokyo (Japan)

The authors have identified two types of polymorphism at the CAR (cell adhesion regulator) locus. One is a conventional TaqI polymorphism and the other is an insertion/deletion polymorphism in the coding region. One has the nucleotide sequence AGTGAGGCA (Ser-Gln-Ala) at nt 271--279, whereas the variant has [und ACAC]AGTGAGGC[und CC]A (Thr-Gln-Ser-Gly-Pro). Although it is not clear whether this variation of amino acids affects the biological function of the gene product, this variant was detected in nine chromosomes among 30 unrelated Japanese individuals. Genetic linkage analysis based on the genotypes of TaqI polymorphism in CEPH families revealed close linkage of CAR to D16S7 and D16S154, which are located in the peritelomeric region of the long arm of chromosome 16. 7 refs., 1 fig.

• OSTI ID: 6287886
• Journal Information: Genomics; (United States), Vol. 16:1; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ADHESION
GENES
HUMAN CHROMOSOME 16
MAPPING
RFLPS
DETECTION
AMINO ACID SEQUENCE
DNA SEQUENCING
GENE MUTATIONS
CHROMOSOMES
HUMAN CHROMOSOMES
MOLECULAR STRUCTURE
MUTATIONS
STRUCTURAL CHEMICAL ANALYSIS
550400* - Genetics