Dose inhomogeneity in interstitial implants using /sup 125/I seeds

Journal Article · Wed Feb 28 23:00:00 EST 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(79)91226-4· OSTI ID:6286918

Ling, C C; Anderson, L L; Shipley, W U

Radioactive /sup 125/I seeds have been used increasingly in intraoperative permanent interstitial implants of certain tumors. Dosimetry calculations of dose distribution in the implants have been based on the assumption of isotropic radiation emission from the /sup 125/I seeds. This paper presents experimental results which show that the radiation fluence around single /sup 125/I seeds is highly anisotropic. Dosimetry calculations based on the measured radiation distribution pattern indicate unusual dosage inhomogeneity within the implant volume. The clinical significance of this effect and approaches to circumvent this potential problem are discussed.

• Research Organization: Harvard Medical School, Boston, MA
• OSTI ID: 6286918
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:3; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

07 ISOTOPE AND RADIATION SOURCES
070200 -- Radiation Sources
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
61 RADIATION PROTECTION AND DOSIMETRY
62 RADIOLOGY AND NUCLEAR MEDICINE
655003* -- Medical Physics-- Dosimetry
ANISOTROPY
BETA DECAY RADIOISOTOPES
DAYS LIVING RADIOISOTOPES
DOSIMETRY
ELECTRON CAPTURE RADIOISOTOPES
ENERGY RANGE
GAMMA DOSIMETRY
IMPLANTS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISODOSE CURVES
ISOTOPES
KEV RANGE
KEV RANGE 10-100
NUCLEI
ODD-EVEN NUCLEI
RADIATION DOSE DISTRIBUTIONS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
SPATIAL DOSE DISTRIBUTIONS
X-RAY DOSIMETRY