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Comparative toxicity of PCBs and related compounds in various species of animals

Journal Article · · Environ. Health Perspect.; (United States)
DOI:https://doi.org/10.1289/ehp.856029· OSTI ID:6284961
There are several basic principles that apply to the clinicopathologic syndrome produced by polychlorinated biphenyls (PCBs). They are as follows: the degree of halogenation and position of the halogen atoms determine the potency of PCB, PBB, CDD, CDF and CN; in a given species of animals, the clinicopathologic syndrome induced by PCB is comparable to that induced by polybrominated biphenyls (PBB), chlorinated dibenzo-p-dioxins (CDD), chlorinated dibenzofurans (CDF), and chlorinated naphthalenes (CN) when an equitoxic dose is achieved; the clinicopathologic syndrome is different in each species of animals; different species of animals vary in their susceptibility to intoxication; intoxication is more readily effected in young animals than in adults; at lethal doses the time between exposure and death is prolonged (> 2 weeks).
Research Organization:
National Institute of Environmental Health Sciences, Research Triangle Park, NC
OSTI ID:
6284961
Journal Information:
Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 60; ISSN EVHPA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BENZOFURANS
BIRDS
BROMINATED AROMATIC HYDROCARBONS
CATTLE
CHICKENS
CHLORINATED AROMATIC HYDROCARBONS
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
DATA
DIOXIN
DOMESTIC ANIMALS
DOSES
EXPERIMENTAL DATA
FOWL
FURANS
GUINEA PIGS
HALOGENATED AROMATIC HYDROCARBONS
HAMSTERS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
INFORMATION
LETHAL DOSES
MAMMALS
MICE
MONKEYS
NAPHTHALENE
NUMERICAL DATA
ORGANIC BROMINE COMPOUNDS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PRIMATES
RABBITS
RATS
RODENTS
RUMINANTS
SENSITIVITY
STRUCTURE-ACTIVITY RELATIONSHIPS
TOXICITY
VERTEBRATES