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Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects

Journal Article · · Proc. Natl. Acad. Sci. U.S.A.; (United States)
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Coupling between cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) was studied using multiple sequential administrations of VO-labeled radiotracers and positron emission tomography. In the resting state an excellent correlation between CBF and CMRO2 was found when paired measurements of CBF and CMRO2 from multiple (30-48) brain regions were tested in each of 33 normal subjects. Regional uncoupling of CBF and CMRO2 was found, however, during neuronal activation induced by somatosensory stimulation. Stimulus-induced focal augmentation of cerebral blood flow (29% mean) far exceeded the concomitant local increase in tissue metabolic rate (mean, 5%), when resting-state and stimulated-state measurements were obtained in each of 9 subjects. Stimulus duration had no significant effect on response magnitude or on the degree of CBF-CMRO2 uncoupling observed. Dynamic, physiological regulation of CBF by a mechanism (neuronal or biochemical) dependent on neuronal firing per se, but independent of the cerebral metabolic rate of oxygen, is hypothesized.

Research Organization:
Washington Univ. School of Medicine, St. Louis, MO
OSTI ID:
6283157
Journal Information:
Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 83:4; ISSN PNASA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHEMICAL REACTIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DYNAMIC FUNCTION STUDIES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
GLUCOSE
HEXOSES
IN VIVO
ISOTOPES
LIGHT NUCLEI
MAMMALS
MAN
METABOLISM
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXIDATION
OXYGEN 15
OXYGEN ISOTOPES
PHYSIOLOGY
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
VERTEBRATES