Environmental neurotoxicity of chemicals and radiation

Journal Article · Tue Jun 01 04:00:00 EDT 1993 · Current Opinion in Neurology and Neurosurgery; (United States)

OSTI ID:6282349

Verity, M A ^[1]

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1. Univ. of California, Los Angeles (United States)

Epidemiologic and societal concerns continue to stimulate studies in the field of environmental neurotoxicology. Although the role of heavy metals, aluminum, and iron are unclear in the etiology of human neurodegenerative disorders, these toxins have provided fertile ground for in vivo and in vitro experimental studies to elucidate their role in neurotoxic injury. Experimental models of clinical syndromes are discussed with special relevance to developmental neurotoxicology. Cycloleucine, tellurium, and 1,3-dinitrobenzene provide models of subacute combined degeneration, primary peripheral nerve demyelination, and thiamine deficiency-like lesions, respectively. Increasing attention is being given to irradiation neurotoxicity, especially in the developing or young central nervous system. A fuller understanding of the pathogenesis of low-dose irradiation injury allows for a clearer understanding of its neurobiology and also provides a more rational approach to understanding an interventional therapy associated with brain irradiation for childhood neoplasia. 43 refs.

• OSTI ID: 6282349
• Journal Information: Current Opinion in Neurology and Neurosurgery; (United States), Journal Name: Current Opinion in Neurology and Neurosurgery; (United States) Vol. 6:3; ISSN CNENE8; ISSN 0951-7383
• Country of Publication: United States
• Language: English

Related Subjects

560151 -- Radiation Effects on Animals-- Man
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALUMINIUM
AMINES
ANTIGENS
AZINES
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
DISEASES
ELEMENTS
ETIOLOGY
HAZARDOUS MATERIALS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IN VITRO
IN VIVO
INJURIES
IRON
IRRADIATION
LOW DOSE IRRADIATION
MATERIALS
MEDICINE
METALS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOGENESIS
PYRIMIDINES
RADIATION EFFECTS
RADIATION INJURIES
RADIOLOGY
RADIOTHERAPY
SEMIMETALS
TELLURIUM
THERAPY
THIAMINE
THIAZOLES
TOXIC MATERIALS
TOXICITY
TOXINS
TRANSITION ELEMENTS
VITAMIN B GROUP
VITAMINS