Synthesis of L- and D-(methyl-/sup 11/C)methionine
This report describes the synthesis of L- and D-(methyl-/sup 11/C)methionine in pure enantiomeric forms. The compounds were prepared routinely approximately 1000 times with less than 20 failures. Starting with carbon-11 (/sup 11/C) methyl iodide, a simple one-carbon precursor produced from a one-pot or a two-pot apparatus, L- and D-(methyl-/sup 11/C)methionine were prepared, respectively, with an optical purity higher than 99% in 40%-90% radiochemical yields. The total time for synthesis, starting from (/sup 11/C)carbon dioxide, was 12-15 min. The crude product usually had a radiochemical purity greater than 95%. The total time for synthesis, including LC purification, was 20-30 min. The radiochemical purity of the product in each case was greater than 98%.
- Research Organization:
- Univ. of Uppsala, Sweden
- OSTI ID:
- 6279219
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
CARBON 11
CHEMICAL REACTION YIELD
METHIONINE
NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CARBON ISOTOPES
CARBOXYLIC ACIDS
DRUGS
EVEN-ODD NUCLEI
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
LIPOTROPIC FACTORS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOISOTOPES
SYNTHESIS
YIELDS
550601* - Medicine- Unsealed Radionuclides in Diagnostics