Uptake and distribution of /sup 3/H-cholesteryl oleyl ether in tissues of cholesterol-fed New Zealand White and Watanabe Heritable Hyperlipidemic rabbits
Thesis/Dissertation
·
OSTI ID:6278626
Cholesterol-fed New Zealand White (CH-FED) and Watanabe Heritable Hyperlipidemic (WHHL) rabbits with minimal, moderate, and severe atherosclerosis were injected with a non-degradable cholesteryl ester analogue, /sup 3/H-cholesteryl oleyl ether (/sup 3/H-COE), to identify organs and cells active in the uptake of plasma cholesteryl ester (CE) at critical stages in the progression of atherosclerosis. The iliac arteries were injured by balloon catheterization to compare the repair process between the two animals. The morphology of the antherosclerotic lesions and the physical state of the arterial lipid were also compared.
- Research Organization:
- Boston Univ., MA (USA)
- OSTI ID:
- 6278626
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ARTERIOSCLEROSIS
CARDIOVASCULAR DISEASES
CHOLESTEROL
DISEASES
DISTRIBUTION
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
PATHOGENESIS
RABBITS
STEROIDS
STEROLS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VASCULAR DISEASES
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ARTERIOSCLEROSIS
CARDIOVASCULAR DISEASES
CHOLESTEROL
DISEASES
DISTRIBUTION
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
PATHOGENESIS
RABBITS
STEROIDS
STEROLS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VASCULAR DISEASES
VERTEBRATES