Correction for intravascular activity in the oxygen-15 steady-state technique is independent of the regional hematocrit

Journal Article · Mon Jun 01 00:00:00 EDT 1987 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1987.75· OSTI ID:6274881

Lammertsma, A A; Baron, J C; Jones, T

The oxygen-15 steady-state technique to measure the regional cerebral metabolic rate for oxygen requires a correction for the nonextracted intravascular molecular oxygen-15. To perform this correction, an additional procedure is carried out using RBCs labeled with /sup 11/CO or C/sup 15/O. The previously reported correction method, however, required knowledge of the regional cerebral to large vessel hematocrit ratio. A closer examination of the underlying model eliminated this ratio. Both molecular oxygen and carbon monoxide are carried by RBCs and are therefore similarly affected by a change in hematocrit.

• Research Organization: Hammersmith Hospital, London, England
• OSTI ID: 6274881
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BRAIN
BLOOD FLOW
OXYGEN
METABOLISM
BIOLOGICAL MODELS
BLOOD COUNT
CARBON 11
CARBON MONOXIDE
ERYTHROCYTES
OXYGEN 15
TRACER TECHNIQUES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBON COMPOUNDS
CARBON ISOTOPES
CARBON OXIDES
CENTRAL NERVOUS SYSTEM
CHALCOGENIDES
ELEMENTS
EVEN-ODD NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MATERIALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NONMETALS
NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
RADIOISOTOPES
551001* - Physiological Systems- Tracer Techniques