Skin notation in the context of workplace exposure standards

Journal Article · Fri Jan 01 00:00:00 EST 1988 · Am. J. Ind. Med.; (United States)

DOI:https://doi.org/10.1002/ajim.4700140612· OSTI ID:6274453

Scansetti, G; Piolatto, G; Rubino, G F

In the establishment of workplace exposure standards, the potential for cutaneous absorption is taken into consideration through the addition of skin notation to the relevant substance. In the TLVs Documentation (ACGIH, 1986) dermal lethal dose to 50% (LD50) or human data are the bases for the assignment of skin notation to 91 of 168 substances. For the other substances, the skin attribution seems to be based on undocumented statements in 24 (14.5%), skin effects in 13 (8%), and analogy in 7 (4%), while in the remaining 33 (20%) any reference is lacking as to the basis for notation of the cutaneous route of entry. Furthermore, since the established cut-off value of 2 g/kg is sometimes bypassed when a notation is added or omitted, the use of dermal LD50 is perplexing. Given the relevance of the skin notation for the validation of threshold limit values (TLVs) in the workplace, a full examination and citation of all available scientific data are recommended when establishing the TLV of substances absorbable through the skin.

• Research Organization: Turin Univ. (Italy)
• OSTI ID: 6274453
• Journal Information: Am. J. Ind. Med.; (United States), Vol. 14:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
XENOBIOTICS
SKIN ABSORPTION
ENVIRONMENTAL EXPOSURE
MAXIMUM PERMISSIBLE EXPOSURE
RECOMMENDATIONS
SKIN DISEASES
TOXICITY
ABSORPTION
DISEASES
SAFETY STANDARDS
STANDARDS
UPTAKE
560300* - Chemicals Metabolism & Toxicology