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Acute light and electron microscopic study of ultraviolet 193-nm excimer laser corneal incisions

Journal Article · · Ophthalmology (Rochester, Minn.); (United States)
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The 193-nm ultraviolet beam from an argon fluoride excimer laser was focused on the corneas of rabbits to produce incisions of the type necessary for radial keratotomy. The energy densities used were in two ranges, 1.0 to 2.1 J/cm2 per pulse and 200 to 700 mJ/cm2 per pulse. The eyes were enucleated and fixed for histologic and electron microscopic examination immediately after exposure. Structural analysis of the higher energy density exposures showed ridging on the surface of the cornea, micro-pitting on the stromal surface inside the cut, and denudation of the endothelium under the ablation zone. The lower energy density incisions did not exhibit significant surface ridging or endothelial cell loss but did exhibit significant stromal swelling during the laser exposure thus making it difficult to produce incisions of a precisely controlled depth. Beam profile measurements and infrared thermal measurements of the cornea surface during laser exposure were made.

Research Organization:
Beckman Laser Institute and Medical Clinic, Irvine, CA (USA)
OSTI ID:
6274256
Journal Information:
Ophthalmology (Rochester, Minn.); (United States), Journal Name: Ophthalmology (Rochester, Minn.); (United States) Vol. 95:10; ISSN OPHTD
Country of Publication:
United States
Language:
English

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Related Subjects

550600 -- Medicine
560400* -- Other Environmental Pollutant Effects
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CORNEA
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
ENDOTHELIUM
EYES
FACE
GAS LASERS
HEAD
LASER RADIATION
LASERS
MAMMALS
MEDICINE
MICROSCOPY
ORGANS
RABBITS
RADIATIONS
SENSE ORGANS
SURGERY
TISSUES
ULTRAVIOLET RADIATION
VERTEBRATES