Management of late radiation-induced rectal injury after treatment of carcinoma of the uterus

Journal Article · Mon Jun 01 04:00:00 EDT 1987 · Surg. Gynecol. Obstet.; (United States)

OSTI ID:6273510

Allen-Mersh, T G; Wilson, E J; Hope-Stone, H F; Mann, C V

Sixty-one of 1418 (4.3 per cent) patients treated with radiation for carcinoma of the uterus from 1963 to 1983 had significant radiation-induced complications of the intestine develop which required a surgical opinion considering further management. Ninety-three per cent of these complications involved the rectum. Florid proctitis resolved within two years of onset in 33 per cent of the patients who were managed conservatively while 22 per cent of the patients died of disseminated disease within the same time period. Surgical treatment was eventually necessary in 39 per cent of the patients who were initially treated conservatively for radiation induced proctitis. Rectal excision with coloanal sleeve anastomosis produced a satisfactory result in eight of 11 patients with severe radiation injury involving the rectum. The incidence of radiation-induced and malignant rectovaginal fistula were similar (1 per cent), but disease-induced symptoms tended to occur earlier after primary treatment (a median of eight months) compared with radiation-induced symptoms (a median of 16 months).

• Research Organization: London Hospital, England
• OSTI ID: 6273510
• Journal Information: Surg. Gynecol. Obstet.; (United States), Journal Name: Surg. Gynecol. Obstet.; (United States) Vol. 6; ISSN SGOBA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOMAS
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
FEMALE GENITALS
GASTROINTESTINAL TRACT
INJURIES
INTESTINES
LARGE INTESTINE
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PROCTITIS
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
RECTUM
SIDE EFFECTS
SURGERY
THERAPY
UTERUS