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Clinical, biochemical, and pathologic features of radiation-associated hyperparathyroidism

Journal Article · · Arch. Intern. Med.; (United States)
;
The clinical, biochemical, and pathologic findings in 43 patients with primary hyperparathyroidism (HPT) and a history of irradiation to the head or neck were compared with those found in a group of 162 patients with HPT without prior irradiation. There were no differences between the groups with regard to mean age at the time of diagnosis, male to female ratio, serum calcium, phosphorus, and parathyroid hormone concentrations; in the frequency of single parathyroid adenomas v multiglandular disease; or in associated nonthyroidal neoplasms. Asymptomatic HPT was found with greater frequency in the irradiated patients. Almost 80% of the patients with a history of irradiation had concomitant thyroid disease, primarily adenomas and carcinomas, while less than 50% of the patients without a history of irradiation had thyroid disease, mainly colloid nodules, at surgery.
Research Organization:
Department of Surgery, Cedars-Sinai Medical Center, UCLA School of Medicine
OSTI ID:
6272499
Journal Information:
Arch. Intern. Med.; (United States), Journal Name: Arch. Intern. Med.; (United States) Vol. 143:1; ISSN AIMDA
Country of Publication:
United States
Language:
English

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Related Subjects

550602 -- Medicine-- External Radiation in Diagnostics-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOMEDICAL RADIOGRAPHY
BODY
BODY AREAS
CHEMISTRY
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HEAD
IRRADIATION
LOCAL IRRADIATION
MEDICINE
NECK
NUCLEAR MEDICINE
ORGANS
PARATHYROID GLANDS
PATIENTS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY
USES