Effects of diethyldithiocarbamate on organ distribution and excretion of cadmium

Journal Article · · Ann. Clin. Lab. Sci.; (United States)

OSTI ID:6271305

Gale, G R; Atkins, L M; Walker, Jr, E M

Sodium diethyldithiocarbamate (DDTC) was evaluated for its efficacy in promoting organ mobilization and excretion of metallothionein-bound cadmium (Cd) using mice which received a single injection of CdCl/sub 2/ X 2.5 H/sub 2/O, 0.03 mg per mouse, along with /sup 109/CdCl/sub 2/ three to six weeks earlier. After seven or 13 i.p. injections of DDTC, 500 mg per kg, over a two or four week interval, DDTC was highly effective in mobilizing Cd from kidney (Ki) and spleen (Sp), but less effective in removing it from liver (Li). Treatment with DDTC moderately enhanced Cd levels in lung (Lu), heart (He) and testes (Te), and increased brain (Br) levels to over 500 percent of control values. Relative accumulation of Cd in organs of control mice were in the order Li greater than Ki greater than Sp greater than Lu greater than He greater than Te greater than Br. The extreme values were Li . 57 percent and Br . 0.07 percent of the Cd administered. Even though a major portion of Cd mobilized was from the kidneys, excretion was apparently exclusively by the fecal route.

• Research Organization: Veterans Administration Medical Center, Medical University of South Carolina, Charleston
• OSTI ID: 6271305
• Journal Information: Ann. Clin. Lab. Sci.; (United States), Journal Name: Ann. Clin. Lab. Sci.; (United States) Vol. 12:6; ISSN ACLSC
• Country of Publication: United States
• Language: English

Related Subjects

550501 -- Metabolism-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CADMIUM
CADMIUM 109
CADMIUM CHLORIDES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CADMIUM ISOTOPES
CARBAMATES
CARBONIC ACID DERIVATIVES
CARBOXYLIC ACID SALTS
CARDIOVASCULAR SYSTEM
CHELATING AGENTS
CHLORIDES
CHLORINE COMPOUNDS
CLEARANCE
DEDTC
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
EXCRETION
GONADS
HALIDES
HALOGEN COMPOUNDS
HEART
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
LUNGS
MALE GENITALS
MAMMALS
METABOLISM
METALLOPROTEINS
METALLOTHIONEIN
METALS
MICE
NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PROTEINS
RADIOISOTOPES
RESPIRATORY SYSTEM
RODENTS
SPLEEN
TESTES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES