Novel biodosimetry methods applied to victims of the Goiania accident

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Health Physics; (USA)

DOI:https://doi.org/10.1097/00004032-199101000-00011· OSTI ID:6270833

Straume, T; Langlois, R G; Lucas, J; Jensen, R H; Bigbee, W L; Ramalho, A T; Brandao-Mello, C E ^[1]

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1. Lawrence Livermore National Lab., CA (USA)

Two biodosimetric methods under development at the Lawrence Livermore National Laboratory were applied to five persons accidentally exposed to a 137Cs source in Goiania, Brazil. The methods used were somatic null mutations at the glycophorin A locus detected as missing proteins on the surface of blood erythrocytes and chromosome translocations in blood lymphocytes detected using fluorescence in-situ hybridization. Biodosimetric results obtained approximately 1 y after the accident using these new and largely unvalidated methods are in general agreement with results obtained immediately after the accident using dicentric chromosome aberrations. Additional follow-up of Goiania accident victims will (1) help provide the information needed to validate these new methods for use in biodosimetry and (2) provide independent estimates of dose.

• OSTI ID: 6270833
• Journal Information: Health Physics; (USA), Journal Name: Health Physics; (USA) Vol. 60:1; ISSN 0017-9078; ISSN HLTPA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACCIDENTS
ALKALI METAL ISOTOPES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
BRAZIL
CESIUM 137
CESIUM ISOTOPES
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
DEVELOPING COUNTRIES
DOSES
ENVIRONMENTAL EXPOSURE
ERYTHROCYTES
HAZARDS
HEALTH HAZARDS
INJURIES
ISOTOPES
LATIN AMERICA
LEUKOCYTES
LYMPHOCYTES
MATERIALS
MUTATIONS
NUCLEI
ODD-EVEN NUCLEI
RADIATION ACCIDENTS
RADIATION DOSES
RADIATION EFFECTS
RADIATION HAZARDS
RADIATION INJURIES
RADIOINDUCTION
RADIOISOTOPES
SOMATIC CELLS
SOMATIC MUTATIONS
SOUTH AMERICA
YEARS LIVING RADIOISOTOPES