Growth factors from genes to clinical application

Conference · Mon Jan 01 00:00:00 EST 1990

OSTI ID:6263083

Sara, V R ^[1]; Hall, K; Low, H ^[2]

---

1. Dept. of Pathology, Karolinska Hospital, Stockholm (SE)
2. Dept. of Endocrinology, Karolinska Hospital, Stockholm (SE)

The last decade has witnessed an explosion in the identification of growth factors and their receptors. This has been greatly facilitated by recombinant DNA technology, which has provided the tools not only to identify these proteins at the gene level but also to produce recombinant proteins for evaluating their biological activities. With the help of such techniques, we are moving toward an understanding of the biosynthesis of growth factors and their receptors, structure-function relationships, as well as mechanisms for intracellular signal transmission. The possibility of modifying these factors has opened new fields of clinical application. In this paper, four major areas of growth factor research are presented: the characterization of growth factor genes and their protein products, growth factor receptors and signal transduction by the receptors to mediate biological action, the biological actions of the various growth factors, and the role of growth factors in health and disease and their possible clinical application. Some of the topics covered include: structure of the IGFs and their variants; isoforms of PDGF receptor types; tyrosine kinase activation; structure of G-proteins in biological membranes; possible therapeutic application of NGF in the treatment of Parkinson's and Alzheimer's diseases; PDGF's possible role in the development of several fibroproliferative diseases and its therapeutic application in wound healing; and the possible use of angiogenic inhibitors in tumor treatment.

• OSTI ID: 6263083
• Report Number(s): CONF-8909383-
• Resource Relation: Conference: 17. nobel conference on growth factors from genes to clinical application, Stockholm (Sweden), 7-8 Sep 1989
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
GROWTH FACTORS
RESEARCH PROGRAMS
AMINO ACID SEQUENCE
BIOLOGICAL FUNCTIONS
CELL MEMBRANES
CELL PROLIFERATION
DNA-CLONING
FSH
GENE RECOMBINATION PROTEINS
GENE REGULATION
LEADING ABSTRACT
MEETINGS
PHENOTYPE
PROTEIN STRUCTURE
RECEPTORS
RECOMBINANT DNA
ABSTRACTS
CELL CONSTITUENTS
CLONING
DNA
DNA HYBRIDIZATION
DOCUMENT TYPES
GONADOTROPINS
HORMONES
HYBRIDIZATION
MEMBRANE PROTEINS
MEMBRANES
MITOGENS
MOLECULAR STRUCTURE
NUCLEIC ACIDS
NUCLEOPROTEINS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
PITUITARY HORMONES
PROTEINS
550200* - Biochemistry
550400 - Genetics