Lack of photoprotection against UVB-induced erythema by immediate pigmentation induced by 382 nm radiation

Journal Article · Fri Nov 01 00:00:00 EST 1985 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12277170· OSTI ID:6255243

Black, G; Matzinger, E; Gange, R W

Immediate pigment darkening (IPD) was induced on the backs of 11 human volunteers of skin types III and IV by exposing the skin to UVA radiation (382 nm). The minimum erythema dose (MED) of UVB radiation was also determined by exposing sites to graduated doses of 304 nm radiation. The order of exposure of distinct anatomic areas was as follow: UVB followed by IPD induction; IPD induction followed by UVB; IPD induction followed 3 h later by UVB; and UVB only. Erythema responses induced by UVB were graded by inspection 24 h later and the MEDs in the 4 areas were compared. The induction of IPD before UVB exposure caused no significant change in the MED compared to sites receiving UVB only, or receiving UVA radiation after UVB, confirming that the IPD reaction does not protect against UVB-induced erythema. There was also no evidence of photorecovery, i.e., an increase in the MED of UVB resulting from exposure to longer wavelength, UV or visible radiation following UVB exposure.

• Research Organization: Massachusetts General Hospital, Boston, MA (United States)
• OSTI ID: 6255243
• Journal Information: J. Invest. Dermatol.; (United States), Vol. 5
• Country of Publication: United States
• Language: English

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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ERYTHEMA
RADIOINDUCTION
SKIN
BIOLOGICAL RADIATION EFFECTS
FAR ULTRAVIOLET RADIATION
MAN
NEAR ULTRAVIOLET RADIATION
ANIMALS
BIOLOGICAL EFFECTS
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SYMPTOMS
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560151* - Radiation Effects on Animals- Man