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Enhancement of thermal killing by polyamines. III. Synergism between spermine and. gamma. radiation in hyperthermic Chinese hamster cells

Journal Article · · Radiat. Res.; (United States)
DOI:https://doi.org/10.2307/3575049· OSTI ID:6254965
;
When combined with heat the polyamine, spermine, enhances the synergistic interaction between hyperthermia (42/sup 0/C) and ..gamma.. radiation in cultured Chinese hamster V79 cells. The enhanced radiation response is reflected in reduction of both D/sub 0/ and D/sub q/ of the survival curves. The shape of the fractionated survival curves indicates that a small heat dose plus spermine is as effective as a large heat dose without spermine in inhibiting the repair of radiation-induced sublethal damage. In addition, spermine also potentiates the effectiveness of heat in inducing transitory thermal resistance. It thus appears that polyamines amplify all the effects of heat that have been so far tested on the cellular level.
Research Organization:
Atomic Energy Commission, Beer-Sheva, Israel
OSTI ID:
6254965
Journal Information:
Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 78:2; ISSN RAREA
Country of Publication:
United States
Language:
English

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Related Subjects

550300 -- Cytology
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560201 -- Thermal Effects-- Cells-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
AMINES
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY TEMPERATURE
CELL CULTURES
COBALT 60
COBALT ISOTOPES
DATA
DATA FORMS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
GAMMA RADIATION
GRAPHS
HYPERTHERMIA
IN VITRO
INFORMATION
INHIBITION
INJURIES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDIUM TEMPERATURE
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATION INJURIES
RADIATIONS
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
SPERMINE
SURVIVAL CURVES
SURVIVAL TIME
SYNERGISM
YEARS LIVING RADIOISOTOPES