Myocardial imaging and metabolic studies with (/sup 17 -123/I)iodoheptadecanoic acid in patients with idiopathic congestive cardiomyopathy

Journal Article · Sat Jan 01 00:00:00 EST 1983 · J. Nucl. Med.; (United States)

OSTI ID:6253227

Hoeck, A; Freundlieb, C; Vyska, K; Loesse, B; Erbel, R; Feinendegen, L E

In twenty patients with primary congestive cardiomyopathy (COCM) the patterns of accumulation and washout of the fatty acid analogue (/sup 17 -123/I)iodoheptadecanoic acid (I-123 HA) were studied. In contrast to patients with ischemic heart disease, where reduced I-123 HA accumulation was correlated with stenosis of the main coronary arteries, thus usually involving larger wall segments, the patients with COCM concentrated I-123 HA heterogeneously in small spotty segments throughout the entire left-ventricular myocardium. The regional washout half-times varied between 15.1 and 116.2 min. It seems that in patients with severe COCM the elimination half-times are more prolonged than in early stages of the disease. There was no correlation between the regional uptake and the elimination half-times. Sequential myocardial imaging with I-123 HA appears useful for noninvasively diagnosis of COCM.

• Research Organization: Nuclear Research Center Juelich GmbH, Federal Republic of Germany
• OSTI ID: 6253227
• Journal Information: J. Nucl. Med.; (United States), Vol. 24:1
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CARDIOVASCULAR DISEASES
DIAGNOSIS
HEART
RADIOISOTOPE SCANNING
IODINE 123
UPTAKE
RADIOPHARMACEUTICALS
BIOLOGICAL HALF-LIFE
COMPARATIVE EVALUATIONS
DIAGNOSTIC USES
IMAGES
METABOLISM
MYOCARDIUM
PATIENTS
QUANTITY RATIO
TRACER TECHNIQUES
USA
BETA DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MUSCLES
NORTH AMERICA
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics