Process for producing astatine-211 for radiopharmaceutical use

Patent · Tue Jul 21 04:00:00 EDT 1987

OSTI ID:6250090

Mirzadeh, S; Lambrecht, R M

A one-step chemical manipulation is described in combination with a distillation and collection process for producing At-211 comprising; a. providing a target of irradiated Bismuth coated to a predetermined thickness of a backing member, b. providing a vapor-producing still operably connected with a condenser that has a water cooled condensate collector formed of a dry silica gel mesh maintained at a temperature above the freezing point of water, and providing an effluent gas filter that is operably connected to receive effluent gas from the condenser, c. heating the target in the still at a temperature in the range of about 630/sup 0/-680/sup 0/C for a time period in the range of 50 to 80 minutes, to evole At-211 vapor from the target, c. providing a dry carrier gas having an oxygen concentration that is sufficient to form Bi/sub 2/O/sub 3/ thereby to essentially preclude vaporization of Bi metal, passing the carrier gas through the still to carry the At-211 vapor to the condenser, and to carry effluent from the condenser to the effluent gas filter, e. eluting At-211 from the condensate collector of the condenser with a controlled volume of eluent containing predetermined solvents that are compatible with a given desired radiopharmaceutical procedure, and f. collecting the At-211 in the controlled volume of eluent for use in the given radiopharmaceutical procedure.

• Assignee: Dept. of Energy, Washington, DC
• Patent Number(s): US 4681727
• OSTI ID: 6250090
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400703* -- Radiochemistry & Nuclear Chemistry-- Radioisotope Production
ADSORBENTS
ALPHA DECAY RADIOISOTOPES
ASTATINE 211
ASTATINE ISOTOPES
BETA DECAY RADIOISOTOPES
BISMUTH
CHEMICAL PREPARATION
CONDENSATES
CONDENSERS
DIMENSIONS
DISTILLATION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
FILTERS
FLUIDS
GASES
HEATING
HEAVY NUCLEI
HIGH TEMPERATURE
HOURS LIVING RADIOISOTOPES
IRRADIATION
ISOTOPES
LABELLED COMPOUNDS
MELTING POINTS
METALS
NUCLEI
ODD-EVEN NUCLEI
PHYSICAL PROPERTIES
RADIOISOTOPES
RADIOPHARMACEUTICALS
SEPARATION PROCESSES
SILICA GEL
SOLVENTS
SYNTHESIS
TARGETS
THERMODYNAMIC PROPERTIES
THICKNESS
TIME DEPENDENCE
TRANSITION TEMPERATURE
VAPORS