Multidisciplinary treatment of primary orbital rhabdomyosarcoma. A single-institution experience

Journal Article · Fri Feb 01 04:00:00 EST 1991 · Cancer (Philadelphia); (USA)

DOI:https://doi.org/10.1002/1097-0142(19910201)67:3<560::AID-CNCR2820670305>3.0.CO;2-T· OSTI ID:6246586

Fiorillo, A; Migliorati, R; Grimaldi, M; Vassallo, P; Canale, G; Tranfa, F; Uccello, G; Fiore, M; Muto, P; Menna, G ^[1]

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1. Univ. of Naples (Italy)

Orbital rhabdomyosarcoma accounts for one-fourth of the primary tumors in the head and neck region. Modern treatment modalities have led to a 2-year survival rate of about 90% in these patients. However, new therapeutic trials are designed to reduce complications and salvage more than 90% of orbital cases. Between 1979 and 1990, 12 children affected by primary orbital rhabdomyosarcoma have been diagnosed and treated at the University of Naples. Ten of them have been uniformly treated by biopsy, followed by immediate radiation and combined chemotherapy. All 12 patients are alive and free of detectable disease, from a minimum of 7 months to a maximum of 123 months after diagnosis. In all children, ocular structures have been spared and the complications observed until now have been few. The above results suggest that the association of immediate radiation therapy and chemotherapy might represent an optimal tool for treatment of orbital rhabdomyosarcoma.

• OSTI ID: 6246586
• Journal Information: Cancer (Philadelphia); (USA), Journal Name: Cancer (Philadelphia); (USA) Vol. 67:3; ISSN 0008-543X; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
BODY
BODY AREAS
CHILDREN
COMBINED THERAPY
DISEASES
HEAD
MYOSARCOMAS
NECK
NEOPLASMS
PATIENTS
RHABDOMYOSARCOMAS
SARCOMAS
SURVIVAL CURVES
THERAPY