Kinetics and imaging of /sup 111/In-labeled autologous platelets in experimental myocardial infarction
The kinetics of accumulation and the external imaging patterns of /sup 111/In-labeled platelets infused in a dog model of left anterior descending coronary artery occlusion with reperfusion were studied. The effects of infarct age and regional residual myocardial blood flow upon platelet accumulation were quantified, and the capacity of /sup 111/In platelets to image the experimental infarction was evaluated qualitatively. The endocardial accumulation of /sup 111/In platelets occurred primarily in infarct zones with residual blood flow less than 0.6 times normal and was maximal (24.98 +/- 2.76 times normal) in the lowest blood flow zone (less than 0.1 times normal). Indium-111 platelet accumulation in the epicardium occurred in the regions with blood flow less than 0.6 times normal and was maximal (17.83 +/- 1.20 times normal) in the lowest blood flow zone (less than 0.1 times normal). The maximal endocardial and epicardial platelet accumulation occurred 24 hours after reperfusion and was significantly decreased at 48 hours. In vivo cardiac images revealed discrete areas of increased myocardial radioactivity uptake in the anterior wall of dogs 24 hours after reperfusion. All images 48 hours after reperfusion were negative. Thus, in the experimental setting, /sup 111/In platelets allow quantification of platelet accumulation after myocardial infarction at a tissue level and provide a noninvasive means of in vivo imaging of reperfused infarcted myocardium.
- Research Organization:
- Department of Cardiac and Thoracic Surgery, Vanderbilt University, Nashville, Tennessee
- OSTI ID:
- 6240379
- Journal Information:
- Circulation; (United States), Vol. 67:1
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BLOOD PLATELETS
DYNAMIC FUNCTION STUDIES
CARDIOVASCULAR DISEASES
DIAGNOSIS
INDIUM 111
DIAGNOSTIC USES
MYOCARDIUM
SCINTISCANNING
BIOLOGICAL MODELS
BLOOD FLOW
CORONARIES
DOGS
LABELLED COMPOUNDS
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD VESSELS
BODY
BODY FLUIDS
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEART
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
USES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques
550301 - Cytology- Tracer Techniques
550901 - Pathology- Tracer Techniques