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Development of a reliable /sup 195m/Hg--/sup 195m/Au, generator for the production of /sup 195m/Au, a short-lived nuclide for vascular imaging

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6240277
; ; ;
A new /sup 195m/Hg (T1/2: 41 hr) leads to /sup 195m/Au (T1/2: 30.6 sec) generator suitable for first-pass as well as steady-state radionuclide angiography studies has been developed. The distribution coefficients, Kd, for mercury (/sup 195m/Hg) and gold (/sup 196m/Au), experimentally evaluated on chelating resin Chelex 100, showed this resin to be suitable as the column packing. /sup 195m/Hg in a Trisma buffer solution at pH 7.40 was loaded on a chelating resin Chelex 100 column, together with gold carrier. /sup 195m/Au was eluted with an aqueous solution of 5% glucose in a 0.01M Trisma buffer at pH 7.70 (25 degrees C). Chemical assessment of the eluate has ensured that the eluted carrier-free gold is by no means colloidal: 80% is found in an ionic form, 20% as an uncharged species. Safe clinical use for routine diagnosis in humans is possible.
Research Organization:
University of Liege, Belgium
OSTI ID:
6240277
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 23:12; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702 -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
CARDIOVASCULAR SYSTEM
CHEMICAL PREPARATION
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GOLD 195
GOLD ISOTOPES
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
MERCURY 195
MERCURY ISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
PERFORMANCE TESTING
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOLOGY
RADIOPHARMACEUTICALS
SECONDS LIVING RADIOISOTOPES
SYNTHESIS
TESTING
USES
VASCULAR DISEASES