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Title: X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons

Abstract

Electrophoretic polymorphisms of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were examined in captive colonies of five subspecies of baboons (Papio hamadryas). Phenotype frequencies and family data verified the X-linked inheritance of the G6PD polymorphism. Insufficient family data were available to confirm autosomal inheritance of the 6PGD polymorphism, but the electrophoretic patterns of variant types (putative heterozygotes) suggested the codominant expression of alleles at an autosomal locus. Implications of the G6PD polymorphism are discussed with regard to its utility as a marker system for research on X-chromosome inactivation during baboon development and for studies of clonal cell proliferation and/or cell selection during the development of atherosclerotic lesions in the baboon model. 61 refs., 1 fig., 4 tabs.

Authors:
; ;  [1]
  1. Southwest Foundation for Biomedical Research, San Antonio, TX (United States)
Publication Date:
OSTI Identifier:
6239667
Resource Type:
Journal Article
Journal Name:
Biochemical Genetics; (United States)
Additional Journal Information:
Journal Volume: 30:11-12; Journal ID: ISSN 0006-2928
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; ARTERIOSCLEROSIS; BIOLOGICAL MODELS; OXIDOREDUCTASES; RFLPS; X CHROMOSOME; INACTIVATION; BABOONS; CELL PROLIFERATION; GLUCOSE; HUMAN X CHROMOSOME; ALDEHYDES; ANIMALS; CARBOHYDRATES; CARDIOVASCULAR DISEASES; CHROMOSOMES; DISEASES; ENZYMES; HETEROCHROMOSOMES; HEXOSES; HUMAN CHROMOSOMES; MAMMALS; MONKEYS; MONOSACCHARIDES; ORGANIC COMPOUNDS; PRIMATES; PROTEINS; SACCHARIDES; VASCULAR DISEASES; VERTEBRATES; 550400* - Genetics

Citation Formats

VandeBerg, J L, Aivaliotis, M J, and Samollow, P B. X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons. United States: N. p., 1992. Web. doi:10.1007/BF02399807.
VandeBerg, J L, Aivaliotis, M J, & Samollow, P B. X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons. United States. doi:10.1007/BF02399807.
VandeBerg, J L, Aivaliotis, M J, and Samollow, P B. Tue . "X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons". United States. doi:10.1007/BF02399807.
@article{osti_6239667,
title = {X-linked glucose-6-phosphate dehydrogenase (G6PD) and autosomal 6-phosphogluconate dehydrogenase (6PGD) polymorphisms in baboons},
author = {VandeBerg, J L and Aivaliotis, M J and Samollow, P B},
abstractNote = {Electrophoretic polymorphisms of glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) were examined in captive colonies of five subspecies of baboons (Papio hamadryas). Phenotype frequencies and family data verified the X-linked inheritance of the G6PD polymorphism. Insufficient family data were available to confirm autosomal inheritance of the 6PGD polymorphism, but the electrophoretic patterns of variant types (putative heterozygotes) suggested the codominant expression of alleles at an autosomal locus. Implications of the G6PD polymorphism are discussed with regard to its utility as a marker system for research on X-chromosome inactivation during baboon development and for studies of clonal cell proliferation and/or cell selection during the development of atherosclerotic lesions in the baboon model. 61 refs., 1 fig., 4 tabs.},
doi = {10.1007/BF02399807},
journal = {Biochemical Genetics; (United States)},
issn = {0006-2928},
number = ,
volume = 30:11-12,
place = {United States},
year = {1992},
month = {12}
}