Tracheal mucous transport in beagles after long-term exposure to 1 ppM sulfur dioxide

Journal Article · Wed Jan 01 04:00:00 EST 1975 · Arch. Environ. Health; (United States)

OSTI ID:6227414

Hirsch, J A; Swenson, E W; Wanner, A

Eight beagles were exposed to 1 ppM SO/sub 2/ via mask for 1.5 hr, twice daily, 5 days/wk for 12 months. Measurement was made of various pulmonary function parameters on anesthetized animals and measurement of tracheal mucous velocity was made with cinebronchofiberscopic examination of Teflon discs (0.68-mm dia, 0.13-mm thick). In 5 of 8 experimentals, increased vascular markings, mucosal edema, and excessive tracheal secretions were observed. There was no effect of SO/sub 2/ on mechanics of breathing or gas exchange parameters. Average mucous velocity was lowered (but not significantly) by SO/sub 2/. However, maximum velocities were significantly lower in SO/sub 2/-treated beagles, as were means of 3 fastest velocities. Frequency of individual disc velocities showed a new peak at the slower rate and decreased frequency at the usual mode. The clockwise movement of discs up the trachea was slowed by SO/sub 2/ although the pattern was not affected.

• OSTI ID: 6227414
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 30; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAGLES
BIOLOGICAL EFFECTS
BIOLOGICAL FUNCTIONS
CHALCOGENIDES
DOGS
IN VIVO
MAMMALS
MUCOUS MEMBRANES
OXIDES
OXYGEN COMPOUNDS
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
TRACHEA
VERTEBRATES