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Treatment of photoaged skin with topical tretinoin increases epidermal-dermal anchoring fibrils

Journal Article · · JAMA, Journal of the American Medical Association; (USA)
;  [1];  [2]; ; ; ;  [3]
  1. Univ. of North Carolina, Chapel Hill (USA)
  2. Univ. of Minnesota, Minneapolis (USA)
  3. Univ. of Michigan, Ann Arbor (USA)
+ Show Author Affiliations

Topical 0.1% tretinoin or vehicle control was applied daily to the forearm skin of six caucasian adults for 4 months. Two-millimeter punch biopsy specimens were obtained from treatment sites at the beginning and end of the study period for electron microscopy. Anchoring fibrils within the epidermal-dermal junction of skin treatment sites were quantitated by blinded, standardized, computer-assisted morphometry. After 4 months of continual daily treatment, skin sites that received topical tretinoin showed double the anchoring fibril density compared with vehicle control sites. The possible mechanism by which topical tretinoin increases anchoring fibrils in skin include the drug's property of inhibiting collagenase, a dermal enzyme that degrades anchoring fibril collagen. The authors speculate that increased numbers of collagenous anchoring fibrils within the papillary dermis of human skin is one of the connective-tissue correlates of the clinical improvement observed in photoaged skin after treatment with topical tretinoin.

OSTI ID:
6226777
Journal Information:
JAMA, Journal of the American Medical Association; (USA), Journal Name: JAMA, Journal of the American Medical Association; (USA) Vol. 263:22; ISSN 0098-7484; ISSN JAMAA
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BIOPSY
BODY
COLLAGEN
CONNECTIVE TISSUE
DIAGNOSTIC TECHNIQUES
ELECTROMAGNETIC RADIATION
ELECTRON MICROSCOPY
EPIDERMIS
EPITHELIUM
MICROSCOPY
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SCLEROPROTEINS
SKIN
TISSUES
TRANSMISSION ELECTRON MICROSCOPY
ULTRAVIOLET RADIATION