Synthesis of three ((trifluoroethyl)amino)pyridines

Journal Article · Thu Jan 01 04:00:00 UTC 1981 · J. Chem. Eng. Data; (United States)

DOI:https://doi.org/10.1021/je00024a046· OSTI ID:6226286

Bissell, E R; Swansiger, R W

The synthesis of o-, m, and p-((trifluoroethyl)amino)pyridine by diborane/tetrahydrofuran reduction of the corresponding trifluoroacetamide is described. The yields were 52%, 83%, and 76%, respectively. The synthesis, in 53% yield, of 2,2,2-trifluoro-N-(4-pyridyl)acetamide is also described.

• Research Organization: Lawrence Livermore National Lab., CA
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 6226286
• Journal Information: J. Chem. Eng. Data; (United States), Journal Name: J. Chem. Eng. Data; (United States) Vol. 26:2; ISSN JCEAA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400301* -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
AMINES
AZINES
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
HETEROCYCLIC COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PYRIDINES
SYNTHESIS
YIELDS