Inotropic effects of ethanol and dihydropyridines on the guinea pig heart atrial muscle

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Life Sciences; (USA)

DOI:https://doi.org/10.1016/0024-3205(90)90345-R· OSTI ID:6225878

Salvatici, R P ^[1]; Gallardo-Carpentier, A; Carpentier, R G ^[2]; Isaacson, R L ^[3]

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1. Univ. of La Frontera, Temuco (Chile)
2. Howard Univ., Washington, DC (USA)
3. State Univ. of New York, Binghamton (USA)

The effects of ethanol and/or dihydropyridines (DHPs) on force of contraction of atrial muscle were studied. Guinea pig atrial strips superfused with Tyrode's solution were driven while recording muscle tension. Bay K 8644 (BAYK) increased, while nimodipine or ethanol reduced, the peak tension developed and the maximum velocity of development of tension. The effects of ethanol were readily reversible, but those of the DHPs were not. The combined actions of ethanol and DHPs were the result of the synergism or antagonism of the drugs tested. The shorter duration of the action of ethanol resulted in the effect of DHPs being still evident well after the exposure to the drugs ended. In summary, ethanol and nimodipine exerted depressant actions on atrial contractile force, while BAYK had opposite effects. The different mechanisms of action may explain the different duration of the effects of ethanol and DHPs.

• OSTI ID: 6225878
• Journal Information: Life Sciences; (USA), Vol. 47:19; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ETHANOL
BIOLOGICAL EFFECTS
MUSCLES
CONTRACTION
PYRIDINES
GUINEA PIGS
SYNERGISM
ALCOHOLS
ANIMALS
AZINES
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology