Successful therapy of convoluted T-lymphoblastic lymphoma in the adult
Fifteen adult patients with biopsy-proven convoluted T-lymphoblastic lymphoma were treated with an aggressive regimen, modified from the LSA2-L2 protocol used for childhood lymphoma. The treatment schema consisted of induction phase, including cyclophosphamide, vincristine, prednisone, adriamycin, and 2000 rads to mediastinum, as well as intrathecal methotrexate. Consolidation phase included cytosine arabinoside, 6-thioguanine, L-asparaginase, and CCNU, along with cranial irradiation and further intrathecal methotrexate. Maintenance consisted of cyclical chemotherapy and intrathecal methotrexate, continuing for a total of 3 yr. Median age in the group was 25 yr (range 16-73). There were 8 males and 7 females. At diagnosis, 9 patients had mediastinal involvement, and 9 had bone marrow involvement. Five of these demonstrated malignant cells in the peripheral blood. Complete clinical response was attained in 11 patients. Three patients achieved partial response. Four complete responders have relapsed, 1 in the central nervous system at 6 mo. and 1 in nodal sites at 3 mo, 1 in multiple sites at 24 mo. and 1 in bone marrow at 42 mo while off all chemotherapy for 6 mos. At this time, median survival of all patients is 28.3 mo. and median relapse-free survival is 21 mo. The median survival for complete responders in excess of 71 mo. while the median relapse-free survival for this group is 41 mo.
- Research Organization:
- Division of Hematology, Department of Medicine, Los Angeles County-University of Southern California Medical Center
- OSTI ID:
- 6222709
- Journal Information:
- Blood; (United States), Vol. 61:1
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHEMOTHERAPY
EVALUATION
LYMPHOMAS
RADIOTHERAPY
MEDIASTINUM
BIOLOGICAL RADIATION EFFECTS
SIDE EFFECTS
BONE MARROW
LOCAL IRRADIATION
PATIENTS
RADIATION DOSES
SURVIVAL TIME
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CHEST
DISEASES
DOSES
HEMATOPOIETIC SYSTEM
IRRADIATION
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
TISSUES
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man