Toxicity of oxygen radicals in cultured pulmonary endothelial cells
Journal Article
·
· J. Toxicol. Environ. Health; (United States)
Superoxide dismutase and catalase, which catalytically remove superoxide radicals and hydrogen perioxide, respectively, each separately protected cultured pulmonary artery endothelial cells from loss of membrane integrity after exposure to oxygen radicals generated either cellularly (polymorphonuclear leukocytes) or chemically (dihydroxyfumarate). Nicotinamide, a precursor of nicotinamide-adenine dinucleotide (NAD) and an inhibitor of ADP-ribose synthetase, also protected cultured endothelial cells from loss of membrane integrity in a concentration-dependent manner after exposure to dihydroxyfumarate.
- Research Organization:
- Univ. of British Columbia Pulmonary Research Lab., Vancouver
- OSTI ID:
- 6220439
- Journal Information:
- J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 13:2-3; ISSN JTEHD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Impairment of lymphocyte adhesion to cultured fibroblasts and endothelial cells by [gamma]-irradiation
Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance
Effect of hyperoxia on glutamate uptake and glutathione levels in calf pulmonary artery endothelial cells
Journal Article
·
Tue Dec 31 23:00:00 EST 1991
· Journal of Immunology; (United States)
·
OSTI ID:7199235
Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance
Journal Article
·
Sun May 15 00:00:00 EDT 1988
· J. Biol. Chem.; (United States)
·
OSTI ID:6771901
Effect of hyperoxia on glutamate uptake and glutathione levels in calf pulmonary artery endothelial cells
Conference
·
Thu May 01 00:00:00 EDT 1986
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
·
OSTI ID:5126662
Related Subjects
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL TISSUES
AZINES
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CATALASE
CELL CONSTITUENTS
CELL CULTURES
CELL MEMBRANES
DICARBOXYLIC ACIDS
ENDOTHELIUM
ENZYME ACTIVITY
ENZYMES
FUMARIC ACID
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
LUNGS
MEMBRANES
NICOTINAMIDE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEROXIDASES
PEROXIDES
PORPHYRINS
PYRIDINES
RADICALS
RESPIRATORY SYSTEM
SUPEROXIDE DISMUTASE
SUPEROXIDE RADICALS
TISSUES
TOXICITY
VITAMIN B GROUP
VITAMINS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
ANIMAL TISSUES
AZINES
BIOLOGICAL EFFECTS
BLOOD VESSELS
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CATALASE
CELL CONSTITUENTS
CELL CULTURES
CELL MEMBRANES
DICARBOXYLIC ACIDS
ENDOTHELIUM
ENZYME ACTIVITY
ENZYMES
FUMARIC ACID
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
HYDROGEN PEROXIDE
LUNGS
MEMBRANES
NICOTINAMIDE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
OXYGEN COMPOUNDS
PEROXIDASES
PEROXIDES
PORPHYRINS
PYRIDINES
RADICALS
RESPIRATORY SYSTEM
SUPEROXIDE DISMUTASE
SUPEROXIDE RADICALS
TISSUES
TOXICITY
VITAMIN B GROUP
VITAMINS