Disposition of americium-241 oxide following inhalation by beagles

Journal Article · Fri Jun 01 00:00:00 EDT 1979 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3574972· OSTI ID:6220049

Craig, D K; Park, J F; Powers, G J; Catt, D L

The disposition of americium-241 in beagles was followed for up to 810 days after a single inhalation exposure to /sup 241/AmO/sub 2/ aerosols having an activity median aerodynamic diameter (AMAD) of 1.3 ..mu..m and a geometric standard deviation 8GSD) of 1.8 for medium (approx. 40 nCi/liter) and high (approx. 340 nCi/liter) concentrations. At low concentrations (< 1 nCi/liter), the aerosols were smaller (AMAD approx. 0.6 ..mu..m) and the distribution broader (GSD approx. 2.6). Excreta were analyzed for up to 30 days postexposure and where appropriate, during the last week before sacrifice. Tissue analyses for /sup 241/Am were conducted on groups of three dogs sacrificed 10, 30, 90, 270, and 810 days postexposure. Forty percent of the final body burden of /sup 241/Am was located in tissues other than the lung parenchyma by 10 days postexposure and only 6% remained in the lung by 810 days postexposure. Translocation was primarilly to the liver and skeleton, with roughly equal fractions of the final body burden in each at all postexposure sacrifice times. There in the gonads was negligible (< 0.05%) for these dogs. Both the rate of translocation and the organ distribution as a function of time are different from those found in dogs that inhaled /sup 238/PuO/sub 2/ or /sup 239/PuO/sub 2/. Therefore it is not appropriate to use data derived from /sup 239/PuO/sub 2/ experiments or observations to predict the behavior of other transuranic isotopes and elements.

• Research Organization: Battelle, Pacific Northwest Lab., Richland, WA
• OSTI ID: 6220049
• Journal Information: Radiat. Res.; (United States), Vol. 78:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMERICIUM 241
EXCRETION
LUNG CLEARANCE
TISSUE DISTRIBUTION
BEAGLES
RADIONUCLIDE KINETICS
LIVER
RADIATION DOSES
LUNGS
LYMPH NODES
TIME DEPENDENCE
SKELETON
AMERICIUM OXIDES
BLOOD
EXPERIMENTAL DATA
EXPOSURE CHAMBERS
FECES
GASTROINTESTINAL TRACT
GONADS
INHALATION
MUSCLES
RADIOACTIVE AEROSOLS
SKIN
TABLES
URINE
ACTINIDE COMPOUNDS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
AEROSOLS
ALPHA DECAY RADIOISOTOPES
AMERICIUM COMPOUNDS
AMERICIUM ISOTOPES
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
BODY FLUIDS
CHALCOGENIDES
CLEARANCE
COLLOIDS
DATA
DATA FORMS
DIGESTIVE SYSTEM
DISPERSIONS
DISTRIBUTION
DOGS
DOSES
GLANDS
HEAVY NUCLEI
INFORMATION
INTAKE
ISOTOPES
LYMPHATIC SYSTEM
MAMMALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RESPIRATORY SYSTEM
SOLS
TRANSURANIUM COMPOUNDS
VERTEBRATES
WASTES
YEARS LIVING RADIOISOTOPES
560172* - Radiation Effects- Nuclide Kinetics &amp; Toxicology- Animals- (-1987)