In vivo and in vitro effects of dexamethasone on leukocyte migration in the rat adjuvant arthritis model

Journal Article · Wed Dec 01 04:00:00 EST 1982 · Inflammation (N.Y.); (United States)

DOI:https://doi.org/10.1007/BF00917308· OSTI ID:6217582

Thieme, T R; Mirkovich, A; Maloney, P; Goodwin, D A

When polymorphonuclear leukocytes (PMNs) and mononuclear cells were isolated from the blood of dexamethasone-treated normal rats, in vitro mononuclear cell migration was inhibited and PMN migration was stimulated in comparison to controls. Inflammogen-induced PMNs showed inhibited cell migration due to dexamethasone treatment. Gamma camera imaging was then used to detect cells in vivo after labeling with /sup 111/In. When the dexamethasone-treated blood cells were injected into adjuvant arthritis diseased rats, mononuclear cells showed depressed migration into the inflamed paws, while PMNs showed stimulated migration into the inflamed paws in comparison to controls. When the recipient adjuvant arthritic animals were treated with dexamethasone, both normal mononuclear cell and normal PMN migration to the inflamed paws were inhibited.

• Research Organization: Institute of Biological Science, Syntex Research, Palo Alto, California
• OSTI ID: 6217582
• Journal Information: Inflammation (N.Y.); (United States), Journal Name: Inflammation (N.Y.); (United States) Vol. 6:4; ISSN INFLD
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FLOW
BODY FLUIDS
CORTICOSTEROIDS
DAYS LIVING RADIOISOTOPES
DEXAMETHASONE
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
IN VITRO
IN VIVO
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
LEUKOCYTES
MAMMALS
MATERIALS
MINUTES LIVING RADIOISOTOPES
MONOCYTES
NEUTROPHILS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATHOLOGY
PREGNANES
RADIOISOTOPES
RATS
RHEUMATIC DISEASES
RODENTS
SENSITIVITY
SKELETAL DISEASES
STEROID HORMONES
STEROIDS
VERTEBRATES