Regional cerebral blood flow imaging: A quantitative comparison of technetium-99m-HMPAO SPECT with C15O2 PET

Journal Article · Mon Oct 01 00:00:00 EDT 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6216904

Gemmell, H G; Evans, N T; Besson, J A; Roeda, D; Davidson, J; Dodd, M G; Sharp, P F; Smith, F W; Crawford, J R; Newton, R H ^[1]

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1. Aberdeen Bio-Medical Imaging Cyclotron Centre, Aberdeen (Scotland)

The aim of this study was to compare technetium-99m-hexamethylpropyleneamineoxime ({sup 99m}Tc-HMPAO) single-photon emission computed tomography (SPECT) with regional cerebral blood flow (rCBF) imaging using positron emission tomography (PET). As investigation of dementia is likely to be one of the main uses of routine rCBF imaging, 18 demented patients were imaged with both techniques. The PET data were compared quantitatively with three versions of the SPECT data. These were, first, data normalized to the SPECT cerebellar uptake, second, data linearly corrected using the PET cerebellar value and, finally, data Lassen corrected for washout from the high flow areas. Both the linearly-corrected (r = 0.81) and the Lassen-corrected (r = 0.79) HMPAO SPECT data showed good correlation with the PET rCBF data. The relationship between the normalized HMPAO SPECT data and the PET data was nonlinear. It is not yet possible to obtain rCBF values in absolute units from HMPAO SPECT without knowledge of the true rCBF in one reference region for each patient.

• OSTI ID: 6216904
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:10; ISSN 0161-5505
• Country of Publication: United States
• Language: English

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