Lung cancer in rats exposed to fibrogenic dusts

Conference · Sun Jan 01 04:00:00 EST 1984

OSTI ID:6214605

Holland, L M; Wilson, J S; Tillery, M I; Smith, D M

Fischer-344 rats were exposed to quartz dusts and to quartz-bearing oil shale dusts in long-term inhalation studies. Aerosol concentrations of 12 mg/m/sup 3/ and 152-176 mg/m/sup 3/ for quartz and shale dusts, respectively, were used in exposure regimens lasting up to two years. Pulmonary fibrosis was observed in most animals surviving beyond 400 days. Adenocarcinomas and epidermoid carcinomas of the lung were observed in animals from all exposure groups, including those exposed to quartz alone. The pulmonary tumors were a late effect, with the earliest lung tumor being observed after 651 days. 13 references, 10 figures, 4 tables.

• Research Organization: Los Alamos National Lab., NM (USA)
• DOE Contract Number: W-7405-ENG-36
• OSTI ID: 6214605
• Report Number(s): LA-UR-84-3856; CONF-8404193-1; ON: DE85005728
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BITUMINOUS MATERIALS
BODY
CARBONACEOUS MATERIALS
CARCINOMAS
CHALCOGENIDES
CHRONIC EXPOSURE
DATA
DISEASES
DUSTS
ENERGY SOURCES
EXPERIMENTAL DATA
FIBROSIS
FOSSIL FUELS
FUELS
INFORMATION
INHALATION
INTAKE
LUNGS
MAMMALS
MATERIALS
MINERALS
NEOPLASMS
NUMERICAL DATA
OIL SHALES
ORGANS
OXIDE MINERALS
OXIDES
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
QUARTZ
RATS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SILICON COMPOUNDS
SILICON OXIDES
VERTEBRATES