Natural killer cell activity in reticulum cell sarcomas (RCS) of SJL/J mice. [Gamma radiation]
Journal Article
·
· Cell. Immunol.; (United States)
Two transplantable reticulum cell sarcomas (RCS) of SJL mice expressed marked levels of natural killer (NK) activity when tested against susceptible /sup 51/Cr-labeled tumor targets. In contrast, normal SJL lymph node and spleen cells demonstrated low levels of NK activity. Neither depletion of macrophages nor pretreatment with anti-Thy-1.2 sera and complement reduced the capacity of RCS cells to express NK activity. Systemic injection of irradiated RCS cells into SJL mice induced a transient increase in NK activity at 3 and 7 days after injection. However, the NK activity observed in recipients of irradiated RCS cells never reached levels comparable to those of control mice injected with viable tumor cells. These data suggest that the transplantable reticulum cell sarcomas of SJL mice may represent a tumor of natural killer cells and thus provide an enriched source of these effectors that may be useful for further characterization of natural cytotoxicity.
- Research Organization:
- Northwestern Univ., Chicago, IL
- OSTI ID:
- 6210455
- Journal Information:
- Cell. Immunol.; (United States), Journal Name: Cell. Immunol.; (United States) Vol. 43:1; ISSN CLIMB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GAMMA RADIATION
IMMUNE REACTIONS
IMMUNE SERUMS
INFORMATION
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
ISOLATED VALUES
ISOTOPES
MACROPHAGES
MAMMALS
MICE
NEOPLASMS
NUCLEI
NUMERICAL DATA
PHAGOCYTES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SARCOMAS
SOMATIC CELLS
TUMOR CELLS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CHROMIUM 51
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXPERIMENTAL DATA
GAMMA RADIATION
IMMUNE REACTIONS
IMMUNE SERUMS
INFORMATION
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
ISOLATED VALUES
ISOTOPES
MACROPHAGES
MAMMALS
MICE
NEOPLASMS
NUCLEI
NUMERICAL DATA
PHAGOCYTES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SARCOMAS
SOMATIC CELLS
TUMOR CELLS
VERTEBRATES