Hydroxyurea or placebo combined with radiation to treat stages IIIB and IV cervical cancer confined to the pelvis. [External. gamma. radiation and intracavitary cesium, cobalt or radium]

Journal Article · Thu Mar 01 04:00:00 EST 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(79)91209-4· OSTI ID:6210259

Hreshchyshyn, M M ^[1]; Aron, B S; Boronow, R C; Franklin, III, E W; Shingleton, H M; Blessing, J A

---

1. State Univ. of New York, Buffalo

In a prospective study by the Gynecologic Oncology Group (GOG), 104 evaluable patients with cervical squamous cell carcinoma Stages IIIB and IVA were randomly assigned to treatment with hydroxyurea or placebo in combination with radiation. There were no deaths resulting from the treatment. Hematologic toxicity was more common and more severe in patients who received hydroxyurea. Response was evaluated in terms of complete tumor regression, duration of progression-free interval, and survival probability. By all those parameters the response was significantly better in the groups of patients receiving hydroxyurea.

• OSTI ID: 6210259
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:3; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
550604 -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ALKALINE EARTH ISOTOPES
AMIDES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD PLATELETS
BODY
BODY AREAS
BODY FLUIDS
BONE MARROW
CARCINOMAS
CESIUM ISOTOPES
COBALT ISOTOPES
DERMATITIS
DIARRHEA
DIGESTIVE SYSTEM
DISEASES
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FEMALE GENITALS
FEMALES
FRACTIONATED IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HEMORRHAGE
HYDROXY COMPOUNDS
HYDROXYUREA
IMMUNITY
IMPLANTS
INJURIES
INTERNAL IRRADIATION
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
LEUKOCYTES
LEUKOPENIA
LOCAL RADIATION EFFECTS
MAMMALS
MAN
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
PELVIS
PRIMATES
RADIATION EFFECTS
RADIATION INJURIES
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIATIONS
RADIODERMATITIS
RADIOINDUCTION
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RADIUM ISOTOPES
SIDE EFFECTS
SKIN
SKIN DISEASES
SYMPTOMS
THERAPY
TISSUES
TOXICITY
UTERUS
VERTEBRATES
VOMITING
WOMEN