Medulloblastoma: treatment results and effect on normal tissues

Journal Article · Thu Mar 01 00:00:00 EST 1979 · Cancer; (United States)

OSTI ID:6210202

Cumberlin, R L ^[1]; Luk, K H; Wara, W M; Sheline, G E; Wilson, C B

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1. Univ. of Pennsylvania, Philadelphia

Thirty-three children under age 20 with medulloblastoma, treated between 1962 and 1976, at the University of California and the Claire Zellerbach Saroni Tumor Institute of Mount Zion Hospital, San Francisco, were retrospectively studied. A relationship between dose and local control rate was suggested by an improved five-year survival in those patients receiving doses greater than 5000 rads to the posterior fossa. The posterior fossa, either alone or with the spinal cord, was the most frequent site of failure. Results of re-irradiation for failure were encouraging and no significant complications were noted. A study of the effects of craniospinal irradiation on the hematopoietic and immune system demonstrated a marked decrease in the peripheral lymphocyte population at the completion of therapy and suggested a functional impairment of the remaining lymphocytes. Other side effects of irradiation included suppression of the hypothalamic-pituitary axis and one instance of brain necrosis. Current treatment policy and proposals for future modifications are discussed.

• OSTI ID: 6210202
• Journal Information: Cancer; (United States), Vol. 43:3; Conference: New Orleans, LA, USA, April 26--30, 1978; Other Information: 60. annual meeting of the American Radium Society
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BRAIN
BIOLOGICAL RADIATION EFFECTS
NEOPLASMS
HEMATOPOIETIC SYSTEM
NECROSIS
RADIOINDUCTION
RADIOTHERAPY
SIDE EFFECTS
CHILDREN
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
GRAPHS
ISOLATED VALUES
LYMPHOCYTES
PATIENTS
RADIATION DOSES
SURVIVAL TIME
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CENTRAL NERVOUS SYSTEM
CONNECTIVE TISSUE CELLS
DATA
DATA FORMS
DISEASES
DOSES
INFORMATION
LEUKOCYTES
MAMMALS
MAN
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
PATHOLOGICAL CHANGES
PRIMATES
RADIATION EFFECTS
RADIOLOGY
SOMATIC CELLS
THERAPY
VERTEBRATES
560151* - Radiation Effects on Animals- Man