Bradykinin as a pain mediator: receptors are localized to sensory neurons, and antagonists have analgesic actions
Autoradiographic studies localize (/sup 3/H)bradykinin receptor binding sites to the substantia gelatinosa, dorsal root, and a subset of small cells in both the dorsal root and trigeminal ganglia of the guinea pig. (/sup 3/H)Bradykinin labeling is also observed over myocardinal/coronary visceral afferent fibers. The localization of (/sup 3/H)bradykinin receptors to nociceptive pathways supports a role for bradykinin in pain mediation. Several bradkykinin antagonists block bradykinin-induced acute vascular pain in the rat. The bradykinin antagonists also relieve bradykinin- and urate-induced hyperalgesia in the rat paw. These results indicate that bradykinin is a physiologic mediator of pain and that bradykinin antagonists have analgesic activity in both acute and chronic pain models.
- Research Organization:
- Nova Pharmaceutical Corporation, Baltimore, MD (USA)
- OSTI ID:
- 6206923
- Journal Information:
- Proc. Natl. Acad. Sci. U.S.A.; (United States), Journal Name: Proc. Natl. Acad. Sci. U.S.A.; (United States) Vol. 85:9; ISSN PNASA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Modulation by orexin A of spontaneous excitatory and inhibitory transmission in adult rat spinal substantia gelatinosa neurons
Referred Pain to the Ipsilateral Forehead and Orbit: An Unusual Phenomenon During Bronchial Artery Embolization
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ANALGESICS
ANIMAL CELLS
ANIMALS
AUTORADIOGRAPHY
BRADYKININ
CENTRAL NERVOUS SYSTEM
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CHEMICAL REACTIONS
CROSS-LINKING
DISTRIBUTION
DRUGS
GUINEA PIGS
INFLAMMATION
KININS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE PROTEINS
NERVE CELLS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
PAIN
PATHOLOGICAL CHANGES
PEPTIDES
PHYSIOLOGY
POLYMERIZATION
POLYPEPTIDES
PROTEINS
RATS
RECEPTORS
RODENTS
SOMATIC CELLS
SPINAL CORD
SYMPTOMS
TISSUE DISTRIBUTION
TRITIUM COMPOUNDS
VERTEBRATES