Polymerized liposomes containing C-glycosides of sialic acid: Potent inhibitors of influenza virus in vitro infectivity
- Lawrence Berkeley Lab., CA (United States)
- Glycomed, Inc., Alameda, CA (United States)
The surface lectin of the influenza virus, hemagglutinin, binds to terminal [alpha]-glycosides of N-acetylneuraminic acid (NeuAc) on cell-surface glycoproteins and glycolipids. Viral binding to cells expression terminal NeuAc residues can be inhibited by [alpha]-O-glycosides of NeuAc (O-sialosides). Recently, dramatic enhancements in the inhibition of viral adhesion to erythrocytes have been achieved using synthetic polyvalent sialosides. In this communication, the authors report that polymerized liposomes containing [alpha]-C-glycosides of sialic acid are potent inhibitors of influenza virus in vitro infectivity. Their results also indicate that the capacity to inhibit hemagglutination does not necessarily reflect the capacity to inhibit in vitro infectivity. 14 refs., 1 tab.
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 6206047
- Journal Information:
- Journal of the American Chemical Society; (United States), Vol. 115:3; ISSN 0002-7863
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
37 INORGANIC
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
GLYCOSIDES
SYNTHESIS
LIPOSOMES
POLYMERIZATION
ANTI-INFECTIVE AGENTS
HEMAGGLUTININS
INFLUENZA VIRUSES
SIALIC ACID
AGGLUTININS
ANTIBODIES
CARBOHYDRATES
CHEMICAL REACTIONS
DRUGS
MICROORGANISMS
MONOSACCHARIDES
ORGANIC COMPOUNDS
PARASITES
SACCHARIDES
VIRUSES
550200* - Biochemistry
550700 - Microbiology
400201 - Chemical & Physicochemical Properties