X-linked mental retardation with heterozygous expression and macrocephaly: Pericentromeric gene localization
Journal Article
·
· American Journal of Medical Genetics
- Prince of Wales Children`s Hospital, Randwick (Australia)
- Adelaide Children`s Hospital (Australia)
A family is described with X-linked mental retardation (XLMR) with affected males in 2 generations. The manifestations are macrocephaly and heterozygous expression. Linkage analysis gives a 2-point lod score of 3.31 ({theta} = 0.0) at the AR, DXS991, and MAOB marker loci. The gene is localized by recombination events between DXS1068 (Xp) and DXS1125 (Xq). This condition in this family may be similar to that described by Atkin et al., 1985. 9 refs., 3 figs., 1 tab.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 62058
- Journal Information:
- American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 4 Vol. 51; ISSN 0148-7299; ISSN AJMGDA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Pericentromeric genes for non-specific X-linked mental retardation (MRX)
Linkage analysis in three families with nonspecific X-linked mental retardation
Regional localization of an X-linked mental retardation gene to Xp21.1-Xp22.13 (MRX38)
Journal Article
·
Fri Jul 15 00:00:00 EDT 1994
· American Journal of Medical Genetics
·
OSTI ID:62056
Linkage analysis in three families with nonspecific X-linked mental retardation
Journal Article
·
Fri Jul 12 00:00:00 EDT 1996
· American Journal of Medical Genetics
·
OSTI ID:476924
Regional localization of an X-linked mental retardation gene to Xp21.1-Xp22.13 (MRX38)
Journal Article
·
Fri Jul 12 00:00:00 EDT 1996
· American Journal of Medical Genetics
·
OSTI ID:476916