Retinoic acid-induced differentiation of retrovirus-infected HL-60 cells is associated with enhanced transcription from the viral long terminal repeat
Journal Article
·
· J. Virol.; (United States)
OSTI ID:6204459
The author infected different human leukemic cell lines with an amphotropic retrovirus vector (designated PA317/N2) which confers G418 resistance and contains the Moloney murine leukemia virus long terminal repeat. In retrovirus-infected G418-resistant HL-60 cells, induction of granulocyte differentiation by retinoic acid was invariably accompanied by a marked increase (5- to 10-fold) in the transcriptional activity of the integrated retroviral long terminal repeat.
- Research Organization:
- Fred Hutchinson Cancer Research Center, Seattle, WA (USA)
- OSTI ID:
- 6204459
- Journal Information:
- J. Virol.; (United States), Vol. 62:11
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
LEUKOCYTES
CELL DIFFERENTIATION
RETINOIC ACID
BIOLOGICAL EFFECTS
VIRUSES
TRANSCRIPTION
LEUKEMIA
TUMOR CELLS
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACID ESTERS
DISEASES
ESTERS
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
MATERIALS
MICROORGANISMS
NEOPLASMS
ORGANIC COMPOUNDS
PARASITES
550701* - Microbiology- Tracer Techniques
LEUKOCYTES
CELL DIFFERENTIATION
RETINOIC ACID
BIOLOGICAL EFFECTS
VIRUSES
TRANSCRIPTION
LEUKEMIA
TUMOR CELLS
ANIMAL CELLS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CARBOXYLIC ACID ESTERS
DISEASES
ESTERS
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
MATERIALS
MICROORGANISMS
NEOPLASMS
ORGANIC COMPOUNDS
PARASITES
550701* - Microbiology- Tracer Techniques