Changes in thyroid function after short-term ozone exposure in rats
Journal Article
·
· J. Environ. Pathol. Toxicol.; (United States)
OSTI ID:6199268
Exposure of male rats to ozone for 24 h at 1 ppM caused a profound depression of the pituitary-thyroid axis as indicated by a highly significant reduction of circulating thyrotropin hormone (TSH), thyroid hormones (T4 and T3), and protein-bound iodine (PBI). The metabolic clearance of TSH was not altered during ozone exposure and the high TSH levels seen in thyroidectomized rats were also not affected. Circulating prolactin (PRL) levels were significantly elevated after exposure. Pituitary TSH and PRL content was considerably increased in ozone-exposed rats; however, only TSH was released significantly above control values in vitro. Thyroid weight was also significantly increased after exposure. The results suggest that the depression of the pituitary-thyroid axis may be an adaptive mechanism during ozone exposure by reducing hypothalamic stimulation via thyrotropin releasing hormone (TRH) and at the same time lifting the hypothalamic catecholamine inhibition on PRL release. Both may be necessary alterations in order to develop tolerance during ozone exposure.
- Research Organization:
- Univ. of California, Berkeley
- DOE Contract Number:
- W-7405-ENG-48
- OSTI ID:
- 6199268
- Journal Information:
- J. Environ. Pathol. Toxicol.; (United States), Journal Name: J. Environ. Pathol. Toxicol.; (United States) Vol. 4; ISSN JEPTD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550200 -- Biochemistry
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHEMISTRY
COMPARATIVE EVALUATIONS
CPB
DYNAMIC FUNCTION STUDIES
ENDOCRINE GLANDS
GLANDS
HORMONES
MAMMALS
MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
OZONE
PBI
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
PROTEINS
RATS
RODENTS
SEX DEPENDENCE
SURGERY
THYROID
THYROID HORMONES
THYROIDECTOMY
THYROXINE
TOLERANCE
TRIIODOTHYRONINE
TSH
VERTEBRATES
551000 -- Physiological Systems
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CHEMISTRY
COMPARATIVE EVALUATIONS
CPB
DYNAMIC FUNCTION STUDIES
ENDOCRINE GLANDS
GLANDS
HORMONES
MAMMALS
MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
OZONE
PBI
PEPTIDE HORMONES
PITUITARY GLAND
PITUITARY HORMONES
PROTEINS
RATS
RODENTS
SEX DEPENDENCE
SURGERY
THYROID
THYROID HORMONES
THYROIDECTOMY
THYROXINE
TOLERANCE
TRIIODOTHYRONINE
TSH
VERTEBRATES