Electrochemically-enhanced electrospray ionization-mass spectrometry
- Oak Ridge National Lab., TN (United States)
The authors discuss here an investigation into the use of the electrochemical redox phenomenon inherent in the ES process and the incorporation of various electrochemical cells on-line with ES as means to form cations from neutral analytes in solution for analysis by ES-MS. The electrophoretic charge separation description of electrospray put forward by Kebarle and co-workers describes an ES sources as a two-electrode electrolysis cell. Based on this theory of operation, for the ES process to occur in positive ion mode an oxidation reaction must occur at the metal/solution interface within the ES needle, ultimately leading to electron flow to ground, to balance the positive-ion charge leaving the needle in the spray.
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 61963
- Report Number(s):
- CONF-9405234--
- Country of Publication:
- United States
- Language:
- English
Similar Records
Analysis of metals in solution using electrospray ionization mass spectrometry
Electrospray as a controlled-current electrolytic cell: Electrochemical ionization of neutral analytes for detection by electrospray mass spectrometry