Role of corticosterone in cleft palate formation in methylmercuric chloride-treated mice
The effect of simultaneous administration of sodium selenite and methylmercuric chloride on plasma corticosterone, and the effect of adrenalectomy and methylmercuric chloride treatment on the incidence of fetal cleft palate in mice were examined. After 6 consecutive days of treatment, methylmercury (as methylmercuric chloride) at 5 mg/kg per day increased plasma corticosterone to approximately twice the concentration observed in the controls. When administered together, selenium (as sodium selenite) at 0.125 to 0.5 mg/kg per day did not affect the increase of plasma corticosterone induced by methylmercuric chloride. Selenite by itself (0.125 to 0.5 mg selenium/kg per day) resulted in an increase of approximately 50% over the controls. Sham opration or adrenalectomy of mice on Day 7 of pregnancy did not result in a significant incidence of cleft palate in the fetuses. However, the administration of methylmercury (5 mg/kg per day) on Days 11, 12, and 13 of gestation to the operated mothers resulted in cleft palate in approximately 30% of the fetuses, regardless of the type of operation. The significance of these findings is discussed.
- Research Organization:
- Univ. of British Columbia, Vancouver
- OSTI ID:
- 6194434
- Journal Information:
- Environ. Res.; (United States), Vol. 24:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CORTICOSTERONE
TOXICITY
METHYLMERCURY
ORAL CAVITY
MALFORMATIONS
SELENIUM
FETUSES
GENETIC EFFECTS
MERCURY CHLORIDES
METABOLISM
MICE
NUTRITION
PLASMA
PREGNANCY
QUANTITY RATIO
SELENITES
SENSITIVITY
ADRENAL HORMONES
ANIMALS
BIOLOGICAL EFFECTS
CHLORIDES
CHLORINE COMPOUNDS
CORTICOSTEROIDS
DIGESTIVE SYSTEM
ELEMENTS
GLUCOCORTICOIDS
HALIDES
HALOGEN COMPOUNDS
HORMONES
HYDROXY COMPOUNDS
KETONES
MAMMALS
MERCURY COMPOUNDS
MERCURY HALIDES
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
PATHOLOGICAL CHANGES
PREGNANES
RODENTS
SELENIUM COMPOUNDS
SEMIMETALS
STEROID HORMONES
STEROIDS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)