Predicting the cure of osteomyelitis under treatment: concise communication

Journal Article · Tue Feb 01 04:00:00 EST 1983 · J. Nucl. Med.; (United States)

OSTI ID:6191630

Graham, G D; Lundy, M M; Frederick, R J; Berger, D E; O'Brien, A W; Brown, T J

The right tibias of sixty-six rabbits were injected with a suspension of Staphylococcus aureus and sodium morrhuate. After four weeks, 43 rabbits developed osteomyelitis and were started on a course of antibiotics. During treatment a /sup 67/Ga scintigram was obtained every two weeks, for up to 10 weeks. During the treatment weeks, 25 rabbits developed negative /sup 67/Ga scintigrams and were killed. All 25 had negative bacteriologic cultures of the right tibia. At the end of 10 wk after start of treatment, the 18 rabbits with persistently positive scintigrams were killed. Eleven of these had positive bacteriologic cultures of the tibia, and seven were negative. The findings suggest that sequential /sup 67/Ga scintigrams may be useful in predicting the cure of osteomyelitis during treatment.

• Research Organization: William Beaumont Army Medical Center, El Paso, Texas
• OSTI ID: 6191630
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 24:2; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
BACTERIA
BETA DECAY RADIOISOTOPES
BODY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVALUATION
GALLIUM 67
GALLIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OSTEOMYELITIS
PATHOLOGY
RABBITS
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SKELETAL DISEASES
SKELETON
STAPHYLOCOCCUS
THERAPY
TIBIA
USES
VERTEBRATES