Serum creatine kinase (CK) activity following exposure to cadmium and/or /sup 60/CO gamma irradiation
Two hundred and sixteen young adult male Sprague-Dawley rats were injected IP every 3 days for 29 days for a total of 9 injections with 0, 1.0, or 2.5 mg CdCl/sub 2//kg body weight. Total cumulative doses were 0, 9.0 or 22.5 mg CdCl/sub 2//kg body weight. Twenty-four hours after the last cadmium injection (day 30), each rat was irradiated with a total-body exposure of 0, 3.62, or 5.43 Gray of gamma (/sup 60/Co) radiation at a dose rate of 3.04 Gray/min. Eight rats from each of the 9 groups were sacrificed on day 1, 7, or 21. Highest levels of the creatine kinase enzyme were seen in radiation groups at day 1, indicating an immediate radiotoxic response. Enzyme levels decreased through day 21 indicating clearance of the enzyme from the plasma. Although statistically significant differences between the groups, cadmium, radiation, or days were not seen, cadmium did protect against radiation. This protective function is not explainable; however, it is speculated that different conformations of metal-induced metallothionein clusters exist to accommodate various metal ions. Further, that each kind of metal ion may have different and unique distribution patterns between the cluster centers which account for different functions.
- Research Organization:
- Texas Woman's Univ., Denton
- OSTI ID:
- 6189363
- Journal Information:
- J. Environ. Sci. Health, Part A; (United States), Vol. A20:6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM
BIOLOGICAL EFFECTS
PHOSPHOTRANSFERASES
ENZYME ACTIVITY
RATS
BIOLOGICAL RADIATION EFFECTS
BLOOD SERUM
CADMIUM CHLORIDES
COBALT 60
EXPERIMENTAL DATA
WHOLE-BODY IRRADIATION
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHLORIDES
CHLORINE COMPOUNDS
COBALT ISOTOPES
DATA
ELEMENTS
ENZYMES
EXTERNAL IRRADIATION
HALIDES
HALOGEN COMPOUNDS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
METALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
PHOSPHORUS-GROUP TRANSFERASES
RADIATION EFFECTS
RADIOISOTOPES
RODENTS
TRANSFERASES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)