Hyperparathyroidism after radiation of the head and neck: a case report and review of the literature

Journal Article · Thu Nov 01 04:00:00 EST 1979 · Am. J. Med. Sci.; (United States)

DOI:https://doi.org/10.1097/00000441-197911000-00006· OSTI ID:6188921

Fiorica, V; Males, J L

A 66-year-old woman was presented with hypercalcemia and a past history of external radiation to the neck. Hyperparathyroidism in this patient was caused by a parathyroid adenoma. The literature associating hyperparathyroidism with prior radiation of the head and neck was reviewed and analyzed. Current evidence supports a relationship between external radiation of the head or neck and the development of hyperparathyroidism as a late complication. Analysis of data available suggests that radiation-association hyperparathyroidism develops after an average latent period of 38 years. Parathyroid adenoma occurred more often than did hyperplasia. Parathyroid carcinoma has not been reported in irradiated patients with hyperparathyroidism. Neither age at radiation exposure, age at diagnosis of hyperparathyroidism, nor interval between exposure and diagnosis was associated with a specific histologic diagnosis (adenoma or hyperplasia).

• Research Organization: Univ. of Oklahoma Health Science Center, Oklahoma City
• OSTI ID: 6188921
• Journal Information: Am. J. Med. Sci.; (United States), Journal Name: Am. J. Med. Sci.; (United States) Vol. 278:3; ISSN AJMSA
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DELAYED RADIATION EFFECTS
DISEASES
DOCUMENT TYPES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
FEMALES
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MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
REVIEWS
SIDE EFFECTS
THERAPY
THYROID