Deficient natural killer cell function in preeclampsia

Journal Article · Mon Nov 01 00:00:00 EST 1982 · Obstet. Gynecol.; (United States)

OSTI ID:6186123

Alanen, A; Lassila, O

Natural killer cell activity of peripheral blood lymphocytes was measured against K-562 target cells with a 4-hour /sup 51/Cr release assay in 15 primigravid women with preeclamptic symptoms. Nineteen primigravid women with an uncomplicated pregnancy and 18 nonpregnant women served as controls. The natural killer cell activity of preeclamptic women was observed to be significantly lower than that of both control groups. Natural killer cells in preeclamptic women responded normally to augmentation caused by interferon. These findings give further evidence for the participation of the maternal immune system in this pregnancy disorder.

• Research Organization: Department of Obstetrics, University of Turku, Finland
• OSTI ID: 6186123
• Journal Information: Obstet. Gynecol.; (United States), Vol. 60:5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
CHROMIUM 51
ISOTOPE APPLICATIONS
LYMPHOCYTES
IMMUNE REACTIONS
REPRODUCTIVE DISORDERS
PATHOLOGY
DYNAMIC FUNCTION STUDIES
INTERFERON
PREGNANCY
ANIMAL CELLS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMIUM ISOTOPES
CONNECTIVE TISSUE CELLS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
ISOTOPES
LEUKOCYTES
MATERIALS
NUCLEI
RADIOISOTOPES
SOMATIC CELLS
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550301 - Cytology- Tracer Techniques