Different radiosensitivities of mast-cell precursors in the bone marrow and skin of mice
Although tissue mast cells are derived from the bone marrow, some descendants of bone marrow-derived precursors retain the ability to proliferate and differentiate into mast cells even after localization in the skin. The purpose of the present study was to determine the D0 values for mast-cell precursors in the bone marrow and those localized in the skin. Bone marrow cells were removed from (WB X C57BL/6)F1-+/+ mice after various doses of irradiation and injected into the skin of the congenic W/Wv mice which were genetically without mast cells. Radiosensitivity of mast-cell precursors in the bone marrow was evaluated by determining the proportion of the injection sites at which mast cells did not appear. For the assay of the radiosensitivity of mast-cell precursors localized in the skin, pieces of skin were removed from beige C57BL/6 (bgJ/bgJ. Chediak-Higashi syndrome) mice after various doses of irradiation and grafted onto the back of the normal C57BL/6 mice. Radiosensitivity of mast-cell precursors in the skin was evaluated by determining the decrease of beige-type mast cells which possessed giant granules. Mast-cell precursors in the bone marrow were much more radiosensitive than those localized in the skin. D0 value was about 100 rad for the former and about 800 rad for the latter.
- Research Organization:
- Institute for Cancer Research, Medical School, Osaka University, Kita-ku, Japan
- OSTI ID:
- 6185235
- Journal Information:
- Radiat. Res.; (United States), Vol. 93:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BONE MARROW CELLS
BIOLOGICAL RADIATION EFFECTS
RADIOSENSITIVITY
MAST CELLS
CELL DIFFERENTIATION
DOSE-RESPONSE RELATIONSHIPS
EXTRACORPOREAL IRRADIATION
INJECTION
MICE
RADIATION DOSES
SKIN
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
CONNECTIVE TISSUE CELLS
DOSES
EXTERNAL IRRADIATION
INTAKE
IRRADIATION
MAMMALS
ORGANS
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560121 - Radiation Effects on Cells- External Source- (-1987)