Metabolism of lithocholic and chenodeoxycholic acids in the squirrel monkey

Journal Article · Sun Sep 01 04:00:00 EDT 1985 · Gastroenterology; (United States)

OSTI ID:6181428

Suzuki, H; Hamada, M; Kato, F

Metabolism of lithocholic acid (LCA) and chenodeoxycholic acid (CDCA) was studied in the squirrel monkey to clarify the mechanism of the lack of toxicity of CDCA in this animal. Radioactive LCA was administered to squirrel monkeys with biliary fistula. Most radioactivity was excreted in the bile in the form of unsulfated lithocholyltaurine. The squirrel monkey thus differs from humans and chimpanzees, which efficiently sulfate LCA, and is similar to the rhesus monkey and baboon in that LCA is poorly sulfated. When labeled CDCA was orally administered to squirrel monkeys, less than 20% of the dosed radioactivity was recovered as LCA and its further metabolites in feces over 3 days, indicating that bacterial metabolism of CDCA into LCA is strikingly less than in other animals and in humans. It therefore appears that LCA, known as a hepatotoxic secondary bile acid, is not accumulated in the squirrel monkey, not because of its rapid turnover through sulfation, but because of the low order of its production.

• Research Organization: Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan
• OSTI ID: 6181428
• Journal Information: Gastroenterology; (United States), Journal Name: Gastroenterology; (United States) Vol. 3; ISSN GASTA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
ANIMALS
BILE
BILE ACIDS
BILIARY TRACT
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
DIGESTIVE SYSTEM
FECES
FISTULAE
HYDROXY COMPOUNDS
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
MONKEYS
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATHOLOGICAL CHANGES
PRIMATES
STEROIDS
STEROLS
TRACER TECHNIQUES
UPTAKE
VERTEBRATES
WASTES