Metabolism and distribution of /sup 14/C- and /sup 35/S-labeled carbon disulfide in immature rats of different ages
The metabolism and distribution of /sup 14/C- and /sup 35/S-CS2 was examined in 1-, 5-, 10-, 20-, 30-, and 40-day-old rats. During a 3-hr period following an ip dose of /sup 14/C-CS2, 58-83% of the dose was expired as CS2 and 4-9% was metabolized to expired CO/sub 2/ depending on age. Thirty- and forty-day-old rats metabolized significantly more CS2 to CO/sub 2/ and expired significantly less CS2 than 1- through 20-day-old rats. At the end of the measured expiration period, only biotransformation products of CS2, which were in part covalently bound, remained in tissues from rats of all ages. Tissue levels of /sup 35/S-CS2-derived radioactivity exceeded levels of /sup 14/C-CS2-derived radioactivity indicating that sulfur metabolites free from the carbon atom of CS2 were formed in rats as young as 1 day of age. The /sup 35/S-CS2-derived radioactivity per g of tissue and thus /sup 35/S covalently bound to tissue protein was significantly higher in 1- through 20-day-old rats than in 30- and 40-day-old rats. Twenty-four hr after dosing, up to 13 times more /sup 35/S-labeled metabolites were covalently bound in organs from 1-day-old rats than in similar organs from 40-day-old rats. The results showed that elimination of the biotransformation products of CS2, in particular the covalently binding sulfur metabolites, was prolonged in newborn rats in comparison to 40-day-old rats.
- Research Organization:
- East Carolina Univ. School of Medicine, Greenville, NC
- OSTI ID:
- 6178711
- Journal Information:
- Drug Metab. Dispos.; (United States), Vol. 15:3
- Country of Publication:
- United States
- Language:
- English
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DISULFIDES
METABOLISM
TISSUE DISTRIBUTION
AGE DEPENDENCE
CARBON 14 COMPOUNDS
CARBON DIOXIDE
METABOLITES
RATS
SULFUR 35
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
EVEN-ODD NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
RADIOISOTOPES
RODENTS
SULFUR ISOTOPES
VERTEBRATES
550501* - Metabolism- Tracer Techniques